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Transcriptional analysis after treatment We used RNA sequencing (RNA-seq) to profile transcriptome-wide changes in human Caco-2 cells infected with SARS-CoV-2, in which clofazimine exhibited antiviral potency comparable to that of remdesivir (Extended Data Fig

In addition, ROS can activate the expression of the nuclear transcription factorkappa, which upregulates the expression of many genes involved in MS, such as tumor necrosis factor and nitric oxide synthase, among others, leading to mitochondrial dysfunction and energy deficits that result in mitochondrial and cellular calcium overload

FASEB J 17(10):11951214

In this sense, studies suggest that both pharmacological classes can reduce depressive symptoms in ulcerative colitis patients, however, the magnitude of the anti-depressant effect of anti-TNF- drugs was significantly higher, reducing the levels of patients at risk for moderate to severe depression (Horst et al., 2015)

Combined use of amlodipine and folic acid are significantly more efficacious than amlodipine alone in lowering plasma homocysteine and blood pressure among hypertensive patients with hyperhomocysteinemia and intolerance to ACEI: A multicenter, randomized, doubleblind, parallelcontrolled clinical trial